H. Kanō, Y. Makisumi, K. Ogata
Feb 20, 1958
Citations
0
Influential Citations
15
Citations
Journal
Chemical & pharmaceutical bulletin
Abstract
4-Ethoxycarbonyl-(III) and 4-cyano-5-aminoisoxazole (IV) were prepared by reacting hydroxylamine and ethyl α-ethoxymethylenecyanoacetate (I) or α-ethoxymethylenemalononitrile (II), respectively. These 5-aminoisoxazoles were very unstable toward bases compared with a compound (XI) substituted in 3-position and the ring cleavage occurred at the nitrogen-oxygen bond with subsequent isomerisation to their corresponding nitriles, (V) and (VIII).