Studies on the mechanism of action of dioctyl sodium sulphosuccinate in the human jejunum.

doi:10.1136/gut.26.10.1008

Paper

Studies on the mechanism of action of dioctyl sodium sulphosuccinate in the human jejunum.

Published Oct 1, 1985 · K. Moriarty, M. Kelly, R. Beetham

Gut

Q1 SJR score

15

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0

Influential Citations

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Abstract

An intestinal perfusion technique has been used to investigate the mechanism of action of the laxative, dioctyl sodium sulphosuccinate, in the human jejunum. Dioctyl sodium sulphosuccinate stimulated net secretion of water, sodium, chloride and potassium and inhibited net absorption of glucose and bicarbonate. These changes in water and solute transport were partially reversed by administration of indomethacin (4 mg/kg/day orally for three days), which suggests that they are mediated in part by endogenous prostaglandins.

Non-RCT

Study Snapshot

Dioctyl sodium sulphosuccinate stimulates water and solute secretion in the human jejunum, with some of its effects mediated by endogenous prostaglandins.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Studies on the mechanism of action of dioctyl sodium sulphosuccinate in the human jejunum.

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References

In vivo reversibility of the jejunal glucose and cation transport alteration caused by intraluminal surfactants in the rat.

Surfactants can alter intestinal transport without causing gross histo-pathological changes, with most effects reversible after 150 minutes.

Bradykinin-stimulated electrolyte secretion in rabbit and guinea pig intestine. Involvement of arachidonic acid metabolites.

Bradykinin stimulates active chloride secretion in the rabbit and guinea pig intestine, likely due to intracellular release of arachidonic acid metabolites.

Bradykinin receptor-mediated chloride secretion in intestinal function

Bradykinin receptors in intestinal mucosa and muscle stimulate chloride secretion, suggesting a physiological and pathological role for kinins in intestinal function.

KININS STIMULATE NET CHLORIDE SECRETION BY THE RAT COLON

Kinins stimulate net chloride secretion in the rat colon, likely through a prostaglandin-dependent pathway.

Effect of vasoactive intestinal polypeptide on active and passive transport in the human jejunum.

VIP in the human jejunum decreases normal absorption of water and electrolytes, mainly through inhibition of active bicarbonate absorption and passive sodium chloride absorption.

Citations

Constipation in pregnancy: causes and remedies

Constipation in pregnancy is common and can be alleviated by a fiber-rich diet, increased fluid intake, and the use of laxatives and probiotics.

Treating constipation during pregnancy.

Laxatives are safe during pregnancy, but short-term use is recommended to avoid dehydration and electrolyte imbalances.

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Understanding opioid-induced bowel dysfunction is crucial for palliative care practitioners to minimize its effects and improve patient quality of life.

Cancer-related constipation

New targeted therapies like lubiprostone and tegaserod show potential in treating cancer-related constipation, while alvimopan and methylnaltrexone show promising results in early trials.

Management of constipation in patients with cancer.

Stool softeners, osmotic agents, stimulant laxatives, lubricants, and enemas can effectively treat constipation in cancer patients, with potential for synergistic effects with other therapeutic agents.