Studies on the mechanism of action of potassium iodide on thyroid protein biosynthesis.

doi:10.1530/ACTA.0.0820298

Paper

Studies on the mechanism of action of potassium iodide on thyroid protein biosynthesis.

Published Jun 1, 1976 · M. Pisarev, L. Aiello

Acta endocrinologica

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8

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Abstract

Potassium iodide (KI) has been shown to have an antigoitrogenic action and to inhibit in vivo thyroid protein biosynthesis. Beef thyroid slices were used to clarify further the mechanism of action of KI. Incubations were performed in Krebs-Ringer-bicarbonate (KRB) buffer under 95%O2 and 5% CO2. KI caused a slight decrease in the uptake of [3H]eucine by the tissue. When labelled leucine incorporation into protein was measured it was found that 10(-6) M KI caused a marked inhibition. Increasing concentrations of KI up to 10(-3) M did not further increase this inhibition. This effect of KI was reduced by simultaneous addition of 0.5 mM KClO4 or 1 mM methylmercaptoimidazole (MMI). In several experiments it was found that equimolar amounts of thyroxine (T4) or triiodothyronine (T3) were more potent than KI in inhibiting thyroid protein biosynthesis. In double plabelled studies KI decreased [3H]leucine incorporation into thyroid soluble proteins and into immunoprecipitable thyroglobulin (T4) while it did not modify that of [14C]galactosamine. When tissue specificity was examined, KI failed to alter [3H]leucine incorporation into proteins either in the liver or in the submaxillary gland. The present results indicate that intracellular KI is necessary to exert its effect on protein synthesis, and that this effect is mediated through a organic form of iodine, probably iodothyronines. This action of KI is specific for the thyroid gland.

In Vitro Study

Study Snapshot

Potassium iodide inhibits thyroid protein biosynthesis through a specific organic form of iodine, probably iodothyronines, in the thyroid gland.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Studies on the mechanism of action of potassium iodide on thyroid protein biosynthesis.

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References

Citations

Toxicological profile for iodine

Iodine exposure can cause various health effects, including death, systemic, immunologic, reproductive, and neurological effects, depending on the route of exposure and exposure duration.

Thyroid vascular conductance: differential effects of elevated plasma thyrotropin (TSH) induced by treatment with thioamides or TSH-releasing hormone.

Elevated plasma TSH levels can increase thyroid vascular conductance, but not thyroid weight, in rats, suggesting distinct populations of thyroid glands.

Autoregulation of thyroid iodide transport: evidence for the mediation of protein synthesis in iodide-induced suppression of iodide transport.

Protein synthesis plays a role in thyroid autoregulation of iodide transport, with cycloheximide suppressing this autoregulation by reducing iodination of a soluble component of the thyroid gland.

Autoregulation by iodine of thyroid protein synthesis: influence of iodine on amino acid transport in cultured thyroid cells.

Iodine autoregulation of thyroid protein synthesis involves regulating the maximum velocity of neutral amino acid uptake through the A, ASC, and L transport systems in cultured thyroid cells.

Uptake, metabolism and action of triiodothyronine in calf-thyroid slices

T3 has a direct action on the thyroid, inhibiting RNA synthesis and showing temperature dependence in uptake and metabolism.

Biochemistry of thyroid regulation under normal and abnormal conditions

Abnormal thyroid growth can be categorized into two main categories: cases caused by excess thyroid stimulators or intrinsic alteration in the thyroid gland.

Effects of Synthetic Iodolipids on Thyroid Function “In Vitro”: Possible Role in Thyroid Regulation

Synthetic iodolipids may play a role in thyroid regulation by inhibiting thyroid function in vitro, suggesting their potential role in thyroid regulation.