L. Qian
2009
Citations
0
Influential Citations
1
Citations
Journal
Journal of Jiangxi Normal University
Abstract
Benzimidazole is an important construction unit which exists in many medicines,it plays an important role in organism.The synthesis of benzimidazole and its ramification is very significative in the development of new medicine and biochemistry.In this paper,1,2-bis(2-benzimidazolyl)ethane were synthesized from o-phenylenediamine and butane diacid in solvent of PPA under microwave irradiation.The yield of 1,2-bis(2-benzimidazolyl)ethane were investigated under mixture ratio,temperature,reaction time,etc.Results show that the appropriate condition are: molar ratio of o-phenylenediamine to butane diacid 2.2∶1,acylation temperature 180 ℃;acylation time 3.5 h,microwave irradiation time 10 minutes.The yield of 1,2-bis(2-benzimidazolyl)ethane is about 50.0%.