Pharmacokinetic Study of Aspirin in Gastrectomized Patients

doi:10.3999/JSCPT.15.291

Paper

Pharmacokinetic Study of Aspirin in Gastrectomized Patients

Published Jun 30, 1984 · S. Mineshita, A. Fukami, M. Ooi

Rinsho Yakuri\/japanese Journal of Clinical Pharmacology and Therapeutics

UNKNOWN SJR score

0

Citations

0

Influential Citations

Full textSemantic Scholar

Abstract

The pharmacokinetics of aspirin was investigated in healthy volunteers and patients who had undergone partial or total gastrectomy. Sixty-six persons participated in the study after verbal consent. Aspirin 5 mg/kg was given orally after an overnight fast, and blood samples were taken at 0.5, 1, 1.5, 2, 4, 6, and 9 hours after aspirin administration. Serum concentrations of salicylic acid were measured spectrophotometrically. For over 40% of the subjects the serum concentration-time curves were best described by a one-compartment model. In the gastrectomized group of patients there was significant reduction in the systemic clearace of aspirin, which resulted in a prolongation of the elimination half-life and an increase in the area under the curve.The absorption kinetics of aspirin was virtually identical in the normal volunteers and the gastrectomized persons, with no significant age-related changes being noted in the pharmacokinetic parameters of aspirin (range: 44-62 yr; mean: 51 yr).

Non-RCT

Study Snapshot

Aspirin pharmacokinetics are similar in gastrectomized patients and healthy volunteers, with no significant age-related changes observed.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Paper

Pharmacokinetic Study of Aspirin in Gastrectomized Patients

Sign up to use Study Snapshot

References

Absorption and elimination of D-propoxyphene, acetyl salicylic acid, and phenazone in a combination tablet (Doleron): comparison between young and elderly subjects.

No significant differences in absorption and elimination of D-propoxyphene, acetyl salicylic acid, and phenazone in Doleron tablets were found between young and elderly subjects.

The gastrointestinal absorption of digoxin in seven patients with gastric or small intestinal reconstructions.

Digoxin absorption in patients with gastric or small intestinal reconstructions is within normal limits, with slightly impaired absorption in patients 6 and 7.

Clinical pharmacokinetics of aspirin.

Aspirin is rapidly absorbed from the gastrointestinal tract and rapidly hydrolyzed into salicylic acid, which must be maintained within a narrow range to obtain adequate anti-inflammatory effect and minimize systemic adverse effects.

Influence of Food on the Bioavailability of Drugs

Food intake can enhance or reduce the bioavailability of various drugs, with different food components having different effects, and the net effect of food on drug bioavailability can only be predicted through clinical studies.

Food, splanchnic blood flow, and bioavailability of drugs subject to first‐pass metabolism

Food generally reduces drug absorption rate but has little impact on absorption extent, except for certain drugs like antibiotics, which can significantly reduce absorption.

Salicylate metabolism in twins. Evidence suggesting a genetic influence and induction of salicylurate formation.

Genetic variations in salicylate metabolism contribute to individual variations in plateau serum salicylate levels, with identical twins showing less variation than fraternal twins.

Variations of serum concentrations and half-life of salicylate in patients with rheumatoid arthritis.

Individualizing aspirin doses is crucial for optimal intensive salicylate therapy in patients with rheumatoid arthritis, as a small increase in dose leads to a large increase in serum levels.

The elimination of salicylic acid in man: serum concentrations and urinary excretion rates.

The elimination of salicylic acid in man is not first order at higher levels, but rather a zero order process, with a limiting value for formation of salicyluric acid.

Citations