Xia-Lian Peng, Di Yao, Yingming Pan
Oct 15, 2011
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Influential Citations
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Journal
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Abstract
Polydatin is a traditional Chinese medicine which shows effective biological activity as antimicrobial and antiviral agent. The secondary structure changes of bovine serum albumin (BSA) were investigated by the methods of Fourier transform infrared spectroscopy (FT-IR), circular dichroism (CD) and Raman spectroscopy. The experimental results indicated that polydatin changed the secondary structure of BSA. The presence of polydatin decreased α-helix content of BSA. The conformations of disulfide bridges and the microenvironment of Tyr, Trp residues were also changed.