Z. Xiu-lan
2009
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Journal
Analysis and Testing Technology and Instruments
Abstract
The 6-Chlorooxindole content,an important intermediate of Ziprasidone,has been determined by the UV spectrophotometry,Ethanol was chosen as the solvent.The concentration vs absorbance was linear in the range of 0.0048~0.02mg/mL,the equation of linear regression was Y = 41.484X + 0.007(R2=0.9994).The average recovery was 99.11%,and RDS was 0.53%(n=6).The results show that this method is simple,sensitive,accurate and reproducible.