Chai Hong-we
2015
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Journal
Fine Chemical Intermediates
Abstract
(S)-Tetrahydrofuran-2-carbonitrile was prepared from the dehydration of(S)-Tetrahydrofuran-2-carboxamide using thionylchloride and dimethylformamide, and then was methylated using methyl magnesium chloride to give oily crude of(S)-1-(tetrahydrofuran-2-yl)ethanone. The crude was further purified using an addition reaction with sodium bisulfite followed by treatment with hydrochloric acid. The total yield for the synthesis was up to 68%.