Li Wei
2009
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Quality indicators
Journal
Journal of Beihua University
Abstract
Objective To investigate the anti-atherosclerosis effects of Panaxadiol saponins(PDS) and analyze its possible mechanism through experimental atherosclerosis in rats.MethodAfter the rats were fed for successive 11 weeks,serum levels of total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),Nitric oxide(NO),Superoxide dismutase(SOD),Malondialdehyde(MDA) were detected respectively.ResultsPDS can decrease serum levels of TC,LDL-c,improve serum levels of NO,improve activity of SOD and decrease the level of MDA.ConclusionPDS can decrease the serum level of blood lipoproteins,protect vascular endothelium,stabilize membrane and prevent AS in this way.