B. Blessington, A. Beiraghi
Nov 28, 1990
Citations
0
Influential Citations
12
Citations
Journal
Journal of Chromatography A
Abstract
Abstract Ethambutol [N,N-ethylenebis(2-aminobutan-1-ol)dihydrochloride] is shown to have S,S absolute stereochemistry by unambiguous synthesis of each of its possible stereomers and chiral chromatography, using Pirkle π interaction chiral stationary phases. Separation of the R,R ; S,S and R,S stereomers together with separation of the entantiomers of 2-aminobutan-1-ol, as their perbenzoyl derivatives, is described. The method is used to study therapeutic tablets. Spectroscopic data is used to characterise these derivatives.