Wu Guo-qiang
2010
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Journal
Modern Chemical Industry
Abstract
A one-pot synthesis of 3,5-dimethyl-4-hydroxybenzonitrile from 3,5-dimethyl-4-hydroxybenzaldehyde and hydroxyamine hydrochloride in solvents such as formic acid,acetic acid,and N,N-dimethylformamide(DMF) is studied.The yields are optimal if in DMF,and the optimization of reaction conditions is carried out.Under such optimum conditions the yield of the nitrile can be 93%,with purity of above 98%,which are determined by HPLC.