Mi Zhi-yuan
2010
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Journal
Guangzhou Chemical Industry
Abstract
Started from 3,5-dichloro-2,4,6-trifluoropyridine,4-amino-3,5-dichloro-6-fluoropyridine-2-ol was obtained by amine substitution and hydroxy substitution.During this step,4-amino-3,5-dichloro-2,6-difluoro-pyridine and 2-amino-3,5-dichloro-4,6-difluoro-pyridine which were by-product were all transformed to 4-amino-3,5-dichloro-6-fluoropyridine-2-ol with high yield and purity.The mechanism was probed and the conclusion was made that it was due to keto-enol tautomerism of pyridine-2-ol in alkaline solution.