Chen Guo-liang
2010
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Journal
Chemical Reagents
Abstract
Quinoline-2-carbonitrile is a key intermediate necessary for the synthesis of quinolyl-heterocyclic compounds.It was synthesized by using 2-quinolinecarboxylic acid as starting material via a three-step process including,esterification,ammonolysis and dehydration in an overall product yield of 72%.This method is easy to operate with ready purification of the product,and the starting material is cheap.It has established a way to prepare quinoline-2-carbonitrile in commercial scale.