L. Tang, C. Lv, D. Liu
Jan 16, 2014
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Journal
Advanced Materials Research
Abstract
(R)-tert-butyl (1-hydroxybut-3-yn-2-yl) carbamate, an key intermediate of the natural product jaspine B which was isolated from various sponges and endowed with cytotoxic activity against several human carcinoma cell lines, was synthesized from L-Serine in overall yield 41% through seven steps, including esterification, Boc protection, acetonization, reduction,Corey-Fuchs reaction and deprotection.