R. De
2002
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0
Influential Citations
1
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Journal
Chemical Reaction Engineering and Technology
Abstract
amino 5 methylthiazole (1) was prepared using 1,2,3 trichloropropane as starting material, which reacted with sodium hydroxide to get 2,3 dichloro 1 propene ,which reacted with potassium thiocyanide, then via isomerization and reacted with ammonia hydroxide, and at last through cyclization. The overall yield was increased from 24.6% to 41.3%. and Meloxicam(6) was also synthetised by the condensation with 2 amino 5 methylthiazole(1) and the intermediate (5) of piroxicam.