Substituted imino and amino derivatives of 4-hydroxycoumarins as novel antioxidant, antibacterial and antifungal agents: synthesis and in vitro assessments.

doi:10.1016/J.FOODCHEM.2009.11.040

Paper

Substituted imino and amino derivatives of 4-hydroxycoumarins as novel antioxidant, antibacterial and antifungal agents: synthesis and in vitro assessments.

Published Jun 15, 2010 · N. Vukovic, S. Sukdolak, S. Solujic

Food Chemistry

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111

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Abstract

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In Vitro Study

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Study Snapshot

Substituted imino and amino derivatives of 4-hydroxycoumarins show promising antioxidant, antibacterial, and antifungal properties, with p-nitrophenol derivative showing comparable radical-scavenging activity to BHT.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Substituted imino and amino derivatives of 4-hydroxycoumarins as novel antioxidant, antibacterial and antifungal agents: synthesis and in vitro assessments.

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References

Synthesis and Antimicrobial Evaluation of Some Novel 2‐Aminothiazole Derivatives of 4‐Hydroxy‐chromene‐2‐one

The 2aminothiazole derivatives of 4hydroxychromene2one 2c-10c show promising antibacterial and antifungal activity against various bacteria and fungi.

Synthesis and protective effects of coumarin derivatives against oxidative stress induced by doxorubicin.

4-Methyl-7,8-dihydroxycoumarin effectively reduces oxidative stress caused by doxorubicin treatment without affecting its antitumoral efficiency in MCF7 cells.

Microtitre plate-based antibacterial assay incorporating resazurin as an indicator of cell growth, and its application in the in vitro antibacterial screening of phytochemicals

The modified resazurin assay is a simple, sensitive, rapid, robust, and reliable method for assessing the antibacterial properties of natural products against various bacterial strains.

Relationship between quantum-chemical descriptors of proton dissociation and experimental acidity constants of various hydroxylated coumarins. Identification of the biologically active species for xanthine oxidase inhibition.

Quantum-chemical descriptors of proton dissociation can accurately predict experimental acidity constants of hydroxylated coumarins, aiding in identifying biologically active species for xanthine oxidase inhibition.

Synthesis and biological activity of Schiff and Mannich bases bearing 2,4-dichloro-5-fluorophenyl moiety.

The synthesized compounds show promising antibacterial and antifungal activity, warranting further investigation for potential pharmaceutical applications.

Citations