SUCCINYL CHOLINE CHLORIDE IN ANÆSTHESIA Preliminary Report

doi:10.1111/j.1365-2044.1952.tb01457.x

Paper

SUCCINYL CHOLINE CHLORIDE IN ANÆSTHESIA Preliminary Report

Published Jul 1, 1952 · D. Adamson, F. Kinsman

Anaesthesia

Q1 SJR score

5

Citations

0

Influential Citations

Full textSemantic Scholar

Abstract

CH,COOCH,N(CH,), C1 I I CH,COOCH,N(CH,), ci Succinyl choline chloride is soluble in water, giving a clear, colourless solution, and is used in 5 % concentration for intravenous injection. It is rapidly destroyed in the body by plasma and erythrocytes, and in vitro by alkalies7. When given intravenously it produces neuro-muscular block by depolarisation of the myo-neural junction, and is hydrolysed by cholinesterasez. As the drug is carried by the blood to the various muscles, a wave of muscular contraction is followed by a period of profound relaxation. Experimentally, in frogs, succinyl choline chloride itself produced a contraction of the isolated nerve muscle preparation, which was counteracted by curare in concentrations adequate to counteract the effect of acetylcholine2. In cats, the previous injection of eserine intravenously markedly prolonged the paralysing effect of succinyl choline chloride, in contrast to eserine which antagonises the action of tubocurarine and has no effect on the block produced by decamethonium2. Succinyl choline chloride does not release histamine or produce bronchospasm. It has no effect on the cardio-vascular system2.

Study Snapshot

Succinyl choline chloride is a safe and effective anesthetic for preventing muscle spasm and preventing muscle injury in anesthesia.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Paper

SUCCINYL CHOLINE CHLORIDE IN ANÆSTHESIA Preliminary Report

Sign up to use Study Snapshot

References

Citations

A Chronology for the Identification and Disclosure of Adverse Effects of Succinylcholine.

Succinylcholine's adverse effects were identified and reported by the manufacturer in a timely manner, but its use remained popular due to its desirable properties.

Succinylcholine and acetazolamide (Diamox) in anaesthesia for ocular surgery

Acetazolamide before succinylcholine in anesthesia can safely prevent the dangerous rise in intraocular pressure, allowing safer use of succinylcholine in ocular surgery.

BIBLIOGRAPHY

Electro-shock therapy has been used in psychiatry for over 50 years, with improvements in treatment methods and reduced complications.