M. A. Moustafa, S. Khalil, A. R. Ebian
Jul 1, 1974
Citations
0
Influential Citations
11
Citations
Journal
Journal of pharmaceutical sciences
Abstract
Abstract Some aqueous suspensions of succinylsulfathiazole exhibited physical instability which was manifested by crystal growth, caking, formation of cement-like precipitates, and difficult resuspendability. Therefore, the polymorphism of succinylsulfathiazole was studied as a probable important factor causing such instability. Methods of preparation of two polymorphs, two hydrates, two solvates, and an amorphous form of succinylsulfathiazole are described. Characterization of these forms was carried out using IR spectroscopy and X-ray crystallography. The interconversion of the crystal forms under various physical conditions was studied. The kinetics of transformation of Form I to the water-stable Form II in aqueous suspensions also are discussed. The half-life value of the transformation obtained from an Arrhenius plot (≃ 14 hr) was in fair agreement with the experimental value (≃ 16 hr) determined for suspensions stored at room temperature.