Sulphur-containing Amino Acids: Protective Role Against Free Radicals and Heavy Metals.

doi:10.2174/0929867324666170609075434

Paper

Sulphur-containing Amino Acids: Protective Role Against Free Radicals and Heavy Metals.

Published Jan 30, 2018 · M. Čolović, V. Vasić, D. Djuric

Current medicinal chemistry

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122

Citations

2

Influential Citations

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Abstract

BACKGROUND Sulphur is an abundant element in biological systems, which plays an important role in processes essential for life as a constituent of proteins, vitamins and other crucial biomolecules. The major source of sulphur for humans is plants being able to use inorganic sulphur in the purpose of sulphur-containing amino acids synthesis. Sulphur-containing amino acids include methionine, cysteine, homocysteine, and taurine. Methionine and cysteine are classified as proteinogenic, canonic amino acids incorporated in protein structure. Sulphur amino acids are involved in the synthesis of intracellular antioxidants such as glutathione and N-acetyl cysteine. Moreover, naturally occurring sulphur-containing ligands are effective and safe detoxifying agents, often used in order to prevent toxic metal ions effects and their accumulation in human body. METHODS Literature search for peer-reviewed articles was performed using PubMed and Scopus databases, and utilizing appropriate keywords. RESULTS This review is focused on sulphur-containing amino acids - methionine, cysteine, taurine, and their derivatives - glutathione and N-acetylcysteine, and their defense effects as antioxidant agents against free radicals. Additionally, the protective effects of sulphur-containing ligands against the toxic effects of heavy and transition metal ions, and their reactivation role towards the enzyme inhibition are described. CONCLUSION Sulphur-containing amino acids represent a powerful part of cell antioxidant system. Thus, they are essential in the maintenance of normal cellular functions and health. In addition to their worthy antioxidant action, sulphur-containing amino acids may offer a chelating site for heavy metals. Accordingly, they may be supplemented during chelating therapy, providing beneficial effects in eliminating toxic metals.

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Sulphur-containing amino acids play a crucial role in maintaining cellular health and may help eliminate toxic metals during chelation therapy.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Sulphur-containing Amino Acids: Protective Role Against Free Radicals and Heavy Metals.

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References

Citations

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The developed sensor PDN effectively detects Cu2+ and L-cysteine in real samples, as well as strong acids and bases, with a low detection limit of 0.113 nM.