Sumatriptan is a Potent Vasoconstrictor of Human Dural Arteries Via a 5-HT1-Like Receptor

doi:10.1046/j.1468-2982.1992.1204202.x

Paper

Sumatriptan is a Potent Vasoconstrictor of Human Dural Arteries Via a 5-HT1-Like Receptor

Published Aug 1, 1992 · I. Jansen, L. Edvinsson, A. Mortensen

Cephalalgia

Q1 SJR score

73

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1

Influential Citations

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Abstract

The action of sumatriptan, putatively a selective 5-HT 1D or 5-HT 1 -like receptor agonist which is effective in the treatment of migraine, has been studied on fresh human dural (middle meningeal) arteries. In low concentrations (10-8 -10-7 M) it was found to be a significantly stronger vasoconstrictor of dural arteries compared to cerebral and temporal arteries. However, its potency was less than that of 5-HT. The sumatriptan-induced vasoconstriction was antagonized by methiothepin (10-9 -10-8 M), but not by ketanserin (10-7 M). The observations suggest that the sumatriptan-induced contraction of the dural artery is mediated via activation of 5-HT 1D or 5-HT 1 -like receptors, whereas it does not appear to activate the 5-HT 2 receptors.

In Vitro Study

Highly Cited

Study Snapshot

Sumatriptan is a potent vasoconstrictor of human dural arteries, primarily through activation of 5-HT1D or 5-HT1-like receptors, but not 5-HT2 receptors.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Sumatriptan is a Potent Vasoconstrictor of Human Dural Arteries Via a 5-HT1-Like Receptor

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References

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Citations

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Vasodilatation is a significant source of pain in migraines, but it does not involve the intracranial vasculature; instead, it involves the extracranial terminal branches of the external carotid artery.