S. Davies, H. Sanganee, P. Szolcsányi
Mar 12, 1999
Citations
0
Influential Citations
58
Citations
Journal
Tetrahedron
Abstract
Abstract (R)-4-Phenyl-5,5-dimethyl-oxazolidin-2-one, readily available from d -phenylglycine, is shown to be an effective chiral auxiliary for stereoselective conjugate additions to attached α,β-unsaturated N-acyl moieties. Its utility is demonstrated by the asymmetric synthesis of the antifungal, antibacterial (−)-Aplysillamide B.