The suppression of the N-nitrosating reaction by chlorogenic acid.

doi:10.1042/BJ3120947

Paper

The suppression of the N-nitrosating reaction by chlorogenic acid.

Published Dec 15, 1995 · Yasuhisa Kono, Hitoshi Shibata, Yasuko KODAMAt

The Biochemical journal

Q1 SJR score

126

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3

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Abstract

N-Nitrosation of a model aromatic amine (2,3-diamino-naphthalene) by the N-nitrosating agent produced by nitrite in acidic solution was inhibited by a polyphenol, chlorogenic acid, which is an ester of caffeic acid quinic acid. Caffeic acid also inhibited the N-nitrosation, but quinic acid did not. 1,2-Benzenediols and 3,4-dihydroxybenzoic acid had inhibitory activities. Chlorogenic acid, caffeic acid, 1,2-benzenediols and 3,4-dihydroxybenzoic acid were able to scavenge the stable free radical, 1,1-diphenyl-2-picrylhydrazyl. Chlorogenic acid was found to be nitrated by acidic nitrite. The kinetic studies and the nitration observed only by bubbling of nitric oxide plus nitrogen dioxide gases indicated that the nitrating agent was nitrogen sesquioxide. The observations showed that the mechanism by which chlorogenic acid inhibited N-nitrosation of 2,3-diamino-naphthalene is due to its ability to scavenge the nitrosating agent, nitrogen sesquioxide. Chlorogenic acid may be effective not only in protecting against oxidative damage but also in inhibiting potentially mutagenic and carcinogenic reactions in vivo.

In Vitro Study

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Study Snapshot

Chlorogenic acid inhibits N-nitrosation of aromatic amines by scavenging nitrogen sesquioxide, potentially protecting against oxidative damage and potentially mutagenic and carcinogenic reactions in vivo.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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The suppression of the N-nitrosating reaction by chlorogenic acid.

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References

Citations

Therapeutic Potential of Chlorogenic Acid in Chemoresistance and Chemoprotection in Cancer Treatment

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