K. V. Laak, H. Scharf
1989
Citations
0
Influential Citations
18
Citations
Journal
Tetrahedron
Abstract
Abstract 4-Hydroxy-5-iodo-2,3-dimethoxy-6-methylbenzoic acid ( 1 ) 5-bromo-4-hydroxy-2,3-dimethoxy-6-methylbenzoic acid ( 2 ) are the polysubstituted aromatic carboxylic acids found in calichemicin antibiotics.l The title compounds are synthesized on preparative scale from readily available methyl 4-O-benzylorsellinate ( 3 ) in six steps without any chromatographic separation needed [( 1 ): 41%, ( 2 ):44%, overall yield].