The syntheses of 4-(2-phenyl-1H-indol-3-yl)cyclohexane-1-carboxylic acids are described. These compounds express potent in vitro inhibition of the human classical complement pathway, and qualitative SAR have been determined. Several of the in vitro active compounds also suppressed the complement dependent reverse passive Arthus reaction (RPAR) in guinea pigs.

4-(2-phenyl-1H-indol-3-yl)cyclohexane-1-carboxylic acids show potent complement inhibitory activities and suppress the complement-dependent reverse passive Arthus reaction in guinea pigs.

Paper

Syntheses and complement inhibitory activities of 4-(2-phenyl-1H-indol-3-yl)cyclohexane-1-carboxylic acids.

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