N. Obasi, C. Okoye, P. Ukoha
2014
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Quality indicators
Journal
chemistry and materials research
Abstract
N-(benzothiazol-2-yl)ethanesulphonamide (ES2ABT) was synthesized by the condensation of 2-aminobenzothiazole and ethanesulphonylchloride in acetone at 130°C. Three metal complexes of manganese(IV), cobalt(II) and zinc(II) of the ligand were synthesized. The compounds were characterized using magnetic susceptibility measurements, mass spectrometry, elemental microanalysis, UV/VIS-spectrophotometry, infrared, proton and 13 C NMR spectroscopies. The antimicrobial tests of the ligand and its metal complexes were carried out on both multi-resistant bacterial strains isolated under clinical conditions and cultured species using agar-well diffusion method. The multi-resistant bacterial strains used were E. coli , P. species, P. aeroginosa and S. aureus which were isolated from dogs. The culture species were P. aeruginosa (ATCC 27853), E. coli (ATCC 25922), S. aureus (ATCC 25923), and the fungi, C. krusei (ATCC 6258) and C. albicans (ATCC 90028). The tests were both in vitro and in vivo . The antimicrobial activities of the compounds were compared with those of Ciprofloxacin and trimethoprim-sulphamethoxazole as antibacterial agents and Fluconazole as an antifungal drug. All the compounds showed varying activities against the cultured typed bacteria and fungi used. The Lethal Concentration (LC 50 ) ranged from <1.00-718.00±56.6 ppm. These are within the permissible concentrations. Key words: N-(benzothiazol-2-yl)ethanesulphonamide, Metal complexes, Antimicrobial, in vitro , in vivo