Syntheses, Characterization and Biological Evaluation of a Series of 2-Phenylamino-5-(2-Chlorophenyl)-1,3,4-Oxadiazole Derivatives

doi:10.3329/DUJPS.V18I1.41894

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Syntheses, Characterization and Biological Evaluation of a Series of 2-Phenylamino-5-(2-Chlorophenyl)-1,3,4-Oxadiazole Derivatives

Published Jun 24, 2019 · S. Kumar, P. Srivastava

Dhaka University Journal of Pharmaceutical Sciences

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Abstract

Electrochemical synthesis of 2-phenylamino-5-(2-chlorophenyl)-1,3,4-oxadiazoles have been carried out in good yields at platinum electrode through the electrochemical oxidation of acyl thiosemicarbazide at room temperature in acetic acid. Two platinum electrodes in the form of square plates were used as working as well as counter electrode and saturated calomel electrode was used as reference electrode. The structure of the compounds was confirmed by IR, NMR, mass spectral and elemental analyses. The antibacterial activity of the derivatives was also assessed and compared with data against a series of Gram-positive Klebsiella pneumoniae, Escherichia coli and Gramnegative bacteria Streptococcus aureus and Bascillus subtilis. The antifungal activity was assessed against the fungal strain Aspergillus niger, Crysosporium pannical, Pellicularia solmanicolor and Candida albicans and compared against the standard antifungal drug Griesvofulvin. Dhaka Univ. J. Pharm. Sci. 18(1): 75-83, 2019 (June)

Study Snapshot

The electrochemical synthesis of 2-phenylamino-5-(2-chlorophenyl)-1,3,4-oxadiazole derivatives shows promising antibacterial and antifungal activity against various bacteria and fungi.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Syntheses, Characterization and Biological Evaluation of a Series of 2-Phenylamino-5-(2-Chlorophenyl)-1,3,4-Oxadiazole Derivatives

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Citations

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