Paper
Synthesis of β-Methylsulfonylated N-Heterocycles from Saturated Cyclic Amines with the Insertion of Sulfur Dioxide.
Published Nov 12, 2020 · Yan He, Jintao Yang, Qimeng Liu
The Journal of organic chemistry
Q2 SJR score
15
Citations
0
Influential Citations
Abstract
An efficient synthesis of β-methylsulfonylated N-heterocycles via FeCl3-catalyzed C(sp3)-H dehydrogenation and C(sp2)-H methylsulfonylation of inactivated cyclic amines with the promotion and participation of inorganic sodium metabisulfite and dicumyl peroxide (DCP) has been developed. Notably, bifunctional DCP acted not only as an oxidant to promote the dehydrogenation but also as a methyl radical to participate in the sulfone formation. With this protocol, a number of β-methylsulfonylated tetrahydropyridines, tetrahydroazepines, and pyrroles were obtained in a facile one-pot manner.
Study Snapshot
This study developed a facile one-pot method for synthesis of -methylsulfonylated N-heterocycles from saturated cyclic amines using FeCl3-catalyzed dehydrogenation and methylsulfonylation, with bifunctional DCP
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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