One pot synthesis of 1,2,4,5-tetrasubstituted-imidazoles catalyzed by trityl chloride in neutral media

doi:10.1039/C4RA10589C

Paper

One pot synthesis of 1,2,4,5-tetrasubstituted-imidazoles catalyzed by trityl chloride in neutral media

Published Nov 12, 2014 · A. Moosavi‐Zare, Zhila Asgari, A. Zare

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30

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Abstract

Trityl chloride (TrCl or Ph3CCl) efficiently catalyzes the one-pot multi-component condensation of benzil with aldehydes, primary amines and ammonium acetate under neutral and solvent-free conditions to give 1,2,4,5-tetrasubstituted imidazoles in high to excellent yields and in short reaction times. Mechanistically, it is attractive that trityl chloride promotes the reaction by in situ generation of trityl carbocation (Ph3C+).

Study Snapshot

Trityl chloride catalyzes the one-pot synthesis of 1,2,4,5-tetrasubstituted imidazoles in high yields and short reaction times, offering a promising method for efficient synthesis of complex organic compounds.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

One pot synthesis of 1,2,4,5-tetrasubstituted-imidazoles catalyzed by trityl chloride in neutral media

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References

Solvent-Free Condensation of Phenols with Aldehydes and Amides Using 3-Methyl-1-sulfonic Acid Imidazolium Chloride

This study presents a solvent-free method for preparing amido-alkyl-phenols, a new class of compounds, by condensation of phenols, aromatic aldehydes, and amides in the presence of 3-methyl-1-sulfonic acid imidazolium chloride.

Synthesis of 2,4,6-Triarylpyridines Using ZrOCl2 under Solvent-Free Conditions

This study presents an efficient one-pot method for the synthesis of 2,4,6-triarylpyridines using ZrOCl2 under solvent-free conditions, offering easy work-up, simple methodology, and reusability of the catalyst.

Design of ionic liquid 1,3-disulfonic acid imidazolium hydrogen sulfate as a dual-catalyst for the one-pot multi-component synthesis of 1,2,4,5-tetrasubstituted imidazoles

The novel ionic liquid 1,3-disulfonic acid imidazolium hydrogen sulfate efficiently catalyzes the one-pot multi-component synthesis of 1,2,4,5-tetrasubstituted imidazoles at 90°C under solvent-free conditions.

Discovery of an in situ carbocationic system using trityl chloride as a homogeneous organocatalyst for the solvent-free condensation of β-naphthol with aldehydes and amides/thioamides/alkyl carbamates in neutral media

Trityl chloride efficiently catalyzes solvent-free multi-component condensation of -naphthol with aromatic aldehydes and amides/thioamides/carbamates in neutral media, producing 1-amido-alkyl-2-naphthol

Organocatalyst trityl chloride efficiently promoted the solvent-free synthesis of 12-aryl-8,9,10,12-tetrahydrobenzo[a]-xanthen-11-ones by in situ formation of carbocationic system in neutral media

Trityl chloride efficiently promotes the solvent-free synthesis of 12-aryl-8,9,10,12-tetrahydrobenzo[a]-xanthen-11-ones by in situ formation of carbocationic systems in neutral media.

Citations