Zang Yang-ling
2008
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Journal
Fine Chemical Intermediates
Abstract
1,3-Acetone dicarboxylic acid and its derivatives were important intermediates for drug synthesis. In this paper diethyl 3-oxopentanedioate was synthesized using anhydrous citric acid as starting material,then reacted with ethanol to produce diethyl 3-oxopentanedioate. The ester product was reduced by KBH4 to afford diethyl 3-hydroxypentanedioate,the total yield was 94% and the purity was 98.5%.