Synthesis of 2-(α-fluorobenzyl)benzimidazole derivatives

doi:10.1016/0022-1139(94)03105-9

Paper

Synthesis of 2-(α-fluorobenzyl)benzimidazole derivatives

Published Feb 1, 1995 · F. Hida, C. Beney, J. Robert

Journal of Fluorine Chemistry

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5

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Abstract

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2-(-fluorobenzyl)benzimidazole derivatives have been prepared by fluorinating benzylic alcohols using 2-chloro-1,1,2-trifluorotriethylamine reagent, with the scope and rates of formation depending on the substituents.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis of 2-(α-fluorobenzyl)benzimidazole derivatives

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References

Protection of Poliovirus-infected Tissue-culture Cells using the I-Benzyl, I-Pentyl and I-Isopropyl Derivatives of 2-(α-Hydroxybenzyl)-benzimidazole

The D-isomer of HBB provides greater protection against types 1, 2 and 3 polio virus than the DL-isomer, with 1-pentyl, 1-isopropyl, and 1-benzyl derivatives showing similar effects.

Organic Fluorine Compounds. Part 43. Applications of (1,1,2‐Trifluoro‐2‐Chloroethyl)‐Diethylamine as Fluorinating Agent

The fluorinating agent (1,1,2-trifluoro-2-chloroethyl)-diethylamine can replace hydroxyl groups in organic compounds with other functional groups, such as carbonyl, ester, and amino-groups, with excellent results.

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