Yanchang Shen*, M. Qi
Jun 1, 1994
Citations
0
Influential Citations
18
Citations
Journal
Journal of Fluorine Chemistry
Abstract
Abstract Reformatsky reactions of bromodifluoroacetate with carbonyl compounds and its applications to the synthesis of 2,2-difluoro-3-hydroxy esters as a means of two-carbon homologation with a difluoro moiety under mild conditions in good to excellent yields are described. In the case of aldehydes and aromatic ketones no catalyst was needed, while in the case of aliphatic ketones, 2 mol% of CeC13 catalyst raises the yields dramatically from 30%–32% to 89%–92%.