Weigao Hu, Meng Li, Guangbin Jiang
Jun 5, 2018
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0
Influential Citations
37
Citations
Journal
Organic letters
Abstract
A novel palladium-catalyzed tandem cyclization of 1-(allyloxy)-2-ethynylbenzene derivatives with isocyanides in the presence of water has been developed. The key intermediates, benzofuran-3-α-carbonyl aldehydes, were obtained through a simple acid hydrolysis process and could serve as precursors for structurally diverse 2,3-difunctionalized benzofuran derivatives such as important 2-benzofurylquinoxalines, benzofuran-3-α-ketoesters and benzofuryl ynediones. This transformation features convenient operation, simple and commercially available starting materials, broad functional-group compatibility, and moderate to good reaction yields.