Navjot S. Sethi, D. Prasad, R. Singh
Feb 29, 2020
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Influential Citations
14
Citations
Quality indicators
Journal
Mini reviews in medicinal chemistry
Abstract
2,4-Thiazolidinedione (2,4-TZD) is a versatile pharmacophore, a privileged scaffold and remarkable sulphur containing heterocyclic compounds with diverse pharmacological activities. The multifarious biological activities, due to different mechanisms of action, low cost and easy availability of 2,4-TZD impressed medicinal chemists to integrate this moiety to develop various lead compounds with diverse therapeutic actions. This resulted in the swift development in the last decade for generating different new potential molecules bearing 2,4-TZD. In this review, author attempt to shape and present the latest investigations (2012 onwards) going on in generating promising 2,4-TZD containing leads compounds. The data has been collected and analyzed to develop the structure-activity relationship (SAR). The SAR and active pharmacophores of various leads accountable for antidiabetic, anticancer, antimicrobial and antioxidant activities have also been illustrated. This review also highlighted some of the important chemical synthetic routes for the preparation of various 2,4-TZD derivatives. This review will definitely serve as a useful source of structural information to medicinal chemists and may be utilized for the strategic design of potent 2,4-TZD derivatives in future.