Zhang Ping-rong
2009
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Journal
Chinese Journal of Medicinal Chemistry
Abstract
Aim To synthesize three important medical intermediates.Methods Ethyl lactate and halogenated hydrocarbon as the starting material were transformed to three target compounds via five steps:alkylation,Grignard reaction,reduction,amination and salt-forming.Results and conclusion The total yields are 18.1%,18.8%,14.3% for 2-methoxypentan-3-amine hydrochloride(1),2-ethoxypentan-3-amine hydrochloride(2) and 2-ethoxy-N-methylpentan-3-amine hydrochloride(3) respectively.The synthesized compounds were characterized by 1H-NMR and MS spectral data.