A. Alizadeh, Vahid Saberi, J. Mokhtari
Oct 1, 2013
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Influential Citations
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Journal
Helvetica Chimica Acta
Abstract
An efficient approach for the preparation of functionalized 2-aryl-2,5-dihydro-5-oxo-4-[2-(phenylmethylidene)hydrazino]-1H-pyrroles is described. The four-component reaction between aldehydes, NH2NH2 ·H 2O, dialkyl acetylenedicarboxylates, and 1-aryl-N,N’-bis(arylmethylidene)methanediamines proceeds in EtOH under reflux in good-to-excellent yields (Scheme 1). The structures of 4 were corroborated spectroscopically (IR, 1 H- and 13 C-NMR, and EI-MS, and, in the case of 4f, by X-ray crystallography). A plausible mechanism for this type of reaction is proposed (Scheme 2).