N-H carbazole synthesis from 2-chloroanilines via consecutive amination and C-H activation.

doi:10.1021/JO061749G

Paper

N-H carbazole synthesis from 2-chloroanilines via consecutive amination and C-H activation.

Published Nov 15, 2006 · R. Bedford, Michael Betham

The Journal of organic chemistry

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140

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1

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Abstract

N-H carbazoles can be produced from 2-chloroanilines and aryl bromides via consecutive catalytic amination and C-H activation. In many instances, this can be done in a tandem manner in one pot. The methodologies developed can be used in the synthesis of a range of carbazoles, including the natural products Clausine P and glycozolidine and a precursor in the synthesis of Clausines H, K, O, and 7-methoxy-O-methylmukonal, and can be extended to the synthesis of indoles.

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Study Snapshot

This study demonstrates a facile method for producing N-H carbazoles from 2-chloroanilines and aryl bromides, potentially extending to the synthesis of indoles.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

N-H carbazole synthesis from 2-chloroanilines via consecutive amination and C-H activation.

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References

Citations

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