Gabriel P. C. Silveira, F. Coelho
Sep 19, 2005
Citations
0
Influential Citations
36
Citations
Journal
Tetrahedron Letters
Abstract
Abstract We describe herein a new and straightforward enantioselective approach to R -(+)-2-ethyl-2,3-dihydrofuran carboxylic acid, the direct precursor of (+)-efaroxan, an α 2 adrenoreceptor antagonist, which is indicated to be used for the treatment of neurodegenerative diseases (Alzheimer and Parkinson), migraine and type II diabetes. Our goal was accomplished using a Baylis–Hillman adduct as starting material. The dihydrobenzofuran acid was obtained in eight steps with an overall yield of 14%.