Synthesis of 2-Nitrophenol-4-Sulfonylamide

Paper

Synthesis of 2-Nitrophenol-4-Sulfonylamide

Published 2001 · Li Yan-yun

Journal of Petrochemical Universities

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Abstract

Nitrophenol-4-sulfonylamide was synthesized by sulfochlorination, ammoniation, hydrolysis from o -nitrochlorobenzene being as raw materials. The reaction conditions were optimized in material proportion, reaction temperature, reaction time. The optimum technological conditions were obtained as the follows:The molar ratio of n ( o -C 6ClH 4NO 2)∶ n (HSO 3Cl)=1∶4; The raw material has been fed in batches and the ration Na 2SO 4 is added, reaction temperature is 140 ℃, reaction time is 6～7 h. The product n (2-nitrochlorobenzene-4-sulfochlorides)∶ n (NH 3)=1∶1.5 has been treated with ammonia water at reaction temperature 38～40 ℃ for 2 h, and treated with 30% NaOH solution at 105 ℃ for 3～4 h, and then phase transfer catalyst is added, finally after acidifying, the product can be obtained.The excellent yield was 70%. The three products obtained in above three phases were characterized by IR.

Study Snapshot

The optimal technological conditions for synthesis of 2-Nitrophenol-4-sulfonylamide from o-nitrochlorobenzene result in a 70% yield and excellent IR characterization.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Synthesis of 2-Nitrophenol-4-Sulfonylamide

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