Meng‐Yang Chang, Chun-Yu Lin, Tsun‐Cheng Wu
Dec 25, 2006
Citations
0
Influential Citations
5
Citations
Journal
Tetrahedron
Abstract
Abstract Synthesis of (2R,3S,4S)-4-aryl-3-hydroxyprolinols has been established starting from 2-benzyloxymethylpyrrolidin-2-one framework, which is derived from commercially available trans-(2S,4R)-4-hydroxyproline. The single diastereomer having a trans–cis relative configuration with C2 and C3 and C3 and C4 is constructed in two one-pot functional group transformations of Grignard addition/dehydration and epoxidation/isomerization as the key steps in moderate yield.