Han Xue-lian
2007
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Journal
Chemical Reagents
Abstract
The synthesis of 3,4-(methylenedioxy)phenylacetic acid was carried out via three-step reactions using piperonal aldehyde as the raw material.At first,2-(3′,4′-methylenedioxyphenyl)-1-(methylsulfinyl)-(methylthio)ethylene was synthesized by the reaction of piperonaldehyde and methylsufinyl(methylthio)methane in the presence of sodium hydroxide,and was then catalyzed by CuCl2 to form ethyl(3,4-methylenedioxyphenyl)acetate.After purification on a silica gel column,the intermediate was treated with 2 mol/L sodium hydroxide solution to give the target compound by acidification with hydrochloric acid.The intermediates and the target compound were characterized by NMR spectra.The synthetic conditions were mild,the total yield of the target compounds were 57.0% with its purity reaching 98.6%(HPLC).