P. Camps, D. Muñoz-Torrero, J. Rull
Dec 10, 2007
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Influential Citations
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Citations
Journal
Tetrahedron-asymmetry
Abstract
Abstract An enantiodivergent preparation of (+)-( R )- and (−)-( S )-3-amino-4,4-dimethyl-1-phenylpyrrolidin-2-one, ( R )- and ( S )- 9 , and several derivatives, from 4,4-dimethyl-1-phenylpyrrolidin-2,3-dione, 4 , and ( R )- or ( S )-1-phenylethylamine, ( R )- or ( S )- 5 , as the chirality transfer agents, is described. Amine ( S )- 9 has also been used as a chiral auxiliary in a diastereoselective Michael reaction.