Yan‐Long Zheng, Mengli Liu, Guanyinsheng Qiu
Mar 22, 2019
Citations
0
Influential Citations
34
Citations
Journal
Tetrahedron
Abstract
Abstract A direct synthesis of 3-(bromomethylene)isobenzofuran-1(3H)-ones from 2-alkynylbenzoic acids is developed through a regioselective 5-exo-dig bromocyclization. The reaction proceeds smoothly with a broad substrate scope. The products can be further elaborated via a palladium-catalyze cross-coupling reaction, or can convert to other heterocycles through simple operation. Preliminary mechanistic studies reveal that this transformation undergoes a radical process.