Zhang Zhi-bao
2011
Citations
0
Influential Citations
0
Citations
Journal
Chemical Reagents
Abstract
3-Mercapto-1-(1,3-thiazolin-2-yl)azetidine hydrochloride has been synthesized by taking 2-thiol-2-thiazoline as raw material,through methylation,nucleophilic substitution SN2 with 3-hydroxyazetidine hydrochloride,activation of hydroxyl with methanesulfonyl chloride,nucleophilic substitution SN2 with potassium thioacetate and basic hydrolysis.Total yield is 51.6%,and purity of product is 98.5%.The structures of intermediates and product have been characterized by melting point,IR,1HNMR and MS techniques.The method has the merits of mild conditions,easy manipulation,high purity and suitability for industrialization.