Synthesis of 3-(quinolin-2-yl)- and 3,6-bis(quinolin-2-yl)-9H-carbazoles

doi:10.3762/bjoc.6.108

Paper

Synthesis of 3-(quinolin-2-yl)- and 3,6-bis(quinolin-2-yl)-9H-carbazoles

Published Oct 8, 2010 · Yang Li, W. Gao

Beilstein Journal of Organic Chemistry

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Abstract

A simple and efficient synthesis of novel 3-(quinolin-2-yl)- and 3,6-bis(quinolin-2-yl)-9H-carbazoles, utilizing sodium ethoxide as a catalyst via a Friedländer condensation reaction between 3-acetyl-9-ethyl-9H-carbazole or 3,6-diacetyl-9-ethyl-9H-carbazole and β-aminoaldehydes or β-aminoketones is described. All of the title compounds were obtained in good yields of 52–72% and their structures were confirmed by IR, 1H NMR, MS, and elemental analysis.

Study Snapshot

This study presents a simple and efficient synthesis of novel 3-(quinolin-2-yl)- and 3,6-bis(quinolin-2-yl)-9H-carbazoles using sodium ethoxide as a catalyst, yielding 52-72% of the compounds with confirmed structures.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis of 3-(quinolin-2-yl)- and 3,6-bis(quinolin-2-yl)-9H-carbazoles

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References

Citations

Synthesis of Methylene Bridged Bis-pyrrolo[3,2-c]carbazoles via an Unusual Vilsmeier–Haack Product of N-Ethylcarbazole

The unexpected result for formylation of N-ethylcarbazole under Vilsmeier-Haack conditions led to the synthesis of novel methylene bridged bis-pyrrolo[3,2-c]carbazoles via Hemetsberger indole synthesis.

A new approach toward the synthesis of 2,4-bis(fluoroalkyl)-substituted quinoline derivatives using fluoroalkyl amino reagent chemistry

This study presents a new two-step approach using Fluoroalkyl Amino Reagents (FARs) for the synthesis of 2,4-bis(fluoroalkyl)-substituted quinoline derivatives with good yields and regioselectivity,

A facile synthesis of novel pyrrolo[3,4-b]quinolin-1-one derivatives

This study demonstrates a facile two-step procedure for synthesizing novel quinoline-based isoindolin-1-one derivatives, which could be potential lead compounds for medicinal chemistry.

Facile Synthesis of Some 3-(Benzimidazol-2-yl)- and 3,6-Di(Benzimidazol-2-yl)-9-ethyl-9H-carbazoles

This study presents a simple and efficient method for synthesizing novel 3-(benzimidazol-2-yl)- and 3,6-di(benzimidazol-2-yl)-9-ethyl-9H-carbazoles using carbazole-3-carbaldehyde

A novel construction of quino-fused tropone skeleton: first synthesis of 12H-benzo[4,5]cyclohepta[1,2-b]quinolin-12-one derivatives

This study successfully synthesized novel quinoline/tropone hybrids using a simple two-step procedure, leading to structurally novel and biologically intriguing compounds.