Synthesis of 4-alkoxy-2-phenylquinoline derivatives as potent antiplatelet agents.

doi:10.1016/S0960-894X(00)00652-1

Paper

DOI: 10.1016/S0960-894X(00)00652-1

Synthesis of 4-alkoxy-2-phenylquinoline derivatives as potent antiplatelet agents.

Published 2001 · T C Ko, M J Hour, J C Lien

Bioorganic & medicinal chemistry letters

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Abstract

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Study Snapshot

4-alkoxy-2-phenylquinoline derivatives show potent antiplatelet activity, with compound 8 being the most potent and potentially acting through inhibition of cyclooxygenase or thromboxane synthetase.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Citations

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Compound 4l, a novel quinoline derivative, effectively induces cell death in breast cancer cells by targeting topoisomerase IIB, leading to double strand breaks and apoptosis.

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Activated carbon-OSO3H powder is an effective catalyst for synthesizing phthalazine and quinoline derivatives in one-pot multicomponent reactions, offering shorter reaction times, cost-effectiveness, reusability, and easy separation.

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Substituted quinolines show promising anticancer, antibacterial, and metabolic enzyme inhibitory properties, with potential for future clinical applications.

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This eco-friendly method for Friedländer quinoline synthesis produces polysubstituted quinolines with good to excellent yields using reusable Nafion NR50 catalyst in ethanol under microwave irradiation.

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DOI: 10.1016/J.TETLET.2019.03.021

Ca(II)-catalyzed diastereoselective formal [4+2] annulation of a 3-component solvent-free povarov reaction

The study developed a diastereoselective, three-component annulation reaction using calcium catalysis, yielding tetrahydro-indenoquinolines and 2-acyl quinolines in one-pot.

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