Lei Zhao, Fei Lei, Yuping Guo
Feb 18, 2017
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Abstract
4-Chloro-6-methoxy-2-methyl-3-nitroquinoline (1) was synthesized from 4-methoxyaniline through three steps including Cyclization, Nitrification and Chlorination. The structure of the target product (1) was confirmed by 1H NMR and MS. This method started with cheap raw materials was of simple experimental operation and mild reaction conditions. It was suitable for large scale pilot study and the yield of the product is achieved to 85%.