Zhao Wenxian, Wang De-kun, Z. Yanli
2004
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Fine chemicals
Abstract
4-Fluoro-3-phenoxytoluene (Ⅳ) was synthesized by Ullmann coupling reaction of 3-bromo-4-fluorotoluene (Ⅲ) and phenol(Ⅰ).When the molar ratio of PhONa (Ⅱ) to Ⅲ was 3∶1 with 15%(mol) of CuO as catalyst and DMA as solvent,the reaction ran at 160~165 ℃ for 5 h to give Ⅳ in 88% yield with purity w(Ⅳ)=98.2% by GC.The structure of Ⅳ was confirmed by elementary analysis,~1HNMR,IR,and MS.