Ling Yong
2006
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Journal
Journal of Nanjing University of Technology
Abstract
4-Fluorocatechol is an important intermediate for medicine.It is also a key precursor in the synthesis of fluorocatecholamines which have pharmaceutical activities.In this paper,4-fluorocatechol was synthesized by the esterification of 4-fluorophenol with acetic anhydride under the catalysis of concentrated sulfuric acid,rearrangement of 4-fluorophenyl acetate with anhydrous aluminum chloride,and Dakin oxidation of 5-Fluoro-2-hydroxyacetophenone.Its overall yield was 45.4%.The structures of 4-fluorocatechol and its intermediates were determinated by IR,H~(1)NMR and MS.