Y. Nishio, Katsuya Uchiyama, M. Kito
Apr 29, 2011
Citations
0
Influential Citations
7
Citations
Journal
Tetrahedron
Abstract
Optimization details and limitations of a novel synthetic method of 4-tert-butyl 2-ethyl 3-amino-1-benzyl-5-dialkylamino-1H-pyrrole-2,4-dicarboxylate derivatives are herein disclosed. This synthesis consists of four steps that include a highly selective cyclization, and can be carried out from starting materials to target compounds without column chromatography purification. The high selectivity is controlled by lithium coordination and steric hindrance caused by tert-butyl ester.