T. Hui
2007
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Journal
Science Technology and Engineering
Abstract
5-methyl-4-isoxazole-formyl hgdrazine, a key intermediate of triazole derivatives, was synthesized via 5 steps. 5-methyl-4-isoxazolecarboxylic acid chloride was obtained from ethyl acetoacetate by condensation, cyclization and hgdrolyzation and chlorination, which was reacted with hgdrazine to give the desired product in an overall yield of 33%.Whereas the influence of the reaction temperature, the materials proportion and the mode of adding materials on synthesis was studied.The structure of compound 6 was comfirmed by IR,1H-NMR,13C-NMR,MS,etc.The improved sythetic route featured accessible starting materials and easy performance.